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KMID : 0357920070410060412
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Korean Journal of Pathology
2007 Volume.41 No. 6 p.412 ~ p.415
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Metastatic Medullary Carcinoma of Thyroid to Breast; A CaseInitially Diagnosed as Primary Invasive Lobular Carcinoma-A Case Report-
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Lee Young-Seok
An Jung-Suk
Kim Chul-Hwan
Yeom Bom-Woo
Choi Jong-Sang
Chae Yang-Seok
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Abstract
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Metastasis to the breast from medullary carcinoma of the thyroid is extremely rare. We report a case of metastatic medullary carcinoma of the thyroid which presented as multiple breast masses with ipsilateral axillary lymphadenopathy in a 48-year-old woman. Six years ago, she underwent total thyroidectomy and neck dissection because of palpable neck masses, with a diagnosis of medullary thyroid carcinoma. Histological features of breast masses showed single-file or linear-cord arrangements, with plasmacytoid appearance, and the initial diagnosis was invasive lobular carcinoma. She underwent modified radical mastectomy. The tumor cells were diffusely positive for E-cadherin, calcitonin and thyroid transcription factor-1 (TTF-1) and were metastatic medullary carcinoma of thyroid. In the patients with a history of medullary carcinoma of the thyroid, a careful examination is necessary for a breast mass composed of solid and cord-like clusters of small round to ovoid cells with plasmacytoid appearance. Immunohistochemical staining for E-cadherin, calcitonin and TTF-1 could be helpful for differential diagnosis.
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KEYWORD
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Medullary carcinoma, Thyroid, Breast, Metastasis, Invasive lobular carcinoma
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